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DNA test for HD

Cornell University has identified the first panel of genetic markers for hip dysplasia in a number of breeds.

They hope to have a DNA test available within the near future, similar to that of Optigen,

where blood can be taken and checked to determine whether a dog is genetically free, a carrier, or will be affected with hip dysplasia.

So far they are working with Rottweilers, German Sheperds, Border Collies, Great Danes, Labradors,

Golden Retrievers and Newfoundlands.

Given the results they have obtained to date, they are very hopeful that they will soon be able to

 come up with a test for all breeds.

source: Poodles in Scandinavia


Article about SA

Please spead this around to people you think needs to know, it's finally been proven that SA is NOT inherited by a simple recessive, it's a lot more complcated than that. This is what most of us have felt during all these years.

I have just received this info and I thought you might find it interesting in case you hadn't already heard.


  http://standardpoodleclub.com/welfare-news.html or look below:

Animal Health Trust

Lay Summary of Progress Report To Determine Genomic Region Associated with  

Sebaceous Adenitis in the Standard Poodle 

Sebaceous Adenitis (SA) is a dermatological condition that has been described in several breeds of dog,

 most commonly in the Standard Poodle. It is a condition in which the sebaceous glands in the skin 

become inflamed and are eventually destroyed,

leading to hair loss and secondary skin infections, and is a significant health and welfare problem.

The Animal Health Trust has collected DNA samples from over 300 Standard Poodles. 

Using the latest genotyping techniques, 

(a Canine SNP(single nucleotide polymorphism) array of 22,362 genome-wide SNPs) 

we have genotyped a subset of 48 samples 

from dogs with a rigorous SA diagnosis, which included 20 affected dogs and 28 unaffected dogs. 

We have been helped enormously 

by the Standard Poodle Club UK in this choice of samples. 

Using this data, we have carried out careful computer analysis to try to 

identify the region in which the SA mutation lies.

The preparation of the DNA samples and their genotyping have been achieved successfully. All 48 samples were genetyped, 

although 4 fell below rigorous acceptability standards and were not included in the analysis. 

The vast majority of the 22,362 SNPs on the array (over99.7%) worked well this is a very impressive result.

The data was analysed using pedigree-based linkage software and association-based software. 

The analyses were carried out successfully: we know this because using identical methods on other diseases and breeds, 

we have been able to identify genome locations linked to the diseases. 

However for the Standard Poodle samples both types of analysis failed to identify any regions 

of the genome which were significantly associated with the disease.

We are confident that the genotyping data we generated was of a very high quality, so the likely explanation of our failure to

identify a region of the genome associated with SA is because the disease is complex, 

and is either caused by more than one gene, or the interaction between gene(s) and the enviroment. 

Alternatively, our controls included a number of subclinically affected dogs whose 

skin biopsy results lead us to mis-categorise them. In either case, the solution is to collect and genotype more samples, 

and any new data can be added to what we already have, thus increasing the chances of success.

This is a disappointing result, but as a result of this investigation we now can say fairly confidently that sebaceous adenitis in 

the Standard Poodle is not inherited as a simple autosomal recessive with a high degree of penetrance, 

and that more samples need to be analysed to identify a genomic region associated with the disease.

We are committed to continuing our study of SA in the Standard Poodle and will continue to collect and 

store samples to successfully analyse SA as a complex trait. 

Data generated during the current study will be saved, and added to additional data generated in 

this subsequent phase of the study. 

Co-Principal Investigators: Cathryn S Mellersh and Mike Boursnell.
Animal Health Trust, Newmarket.


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